mouse 1200011M11RIK shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Smg8.
shAAV-250183
AAV-m-1200011M11RIK-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Smg8 (smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1200011M11Rik
Description (Vector)
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.
Gene ID
74133
Gene Name (Vector)
smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
Gene Symbol
Smg8
ORF Size (aa)
2976
ORF Size (bp)
2976 bp
RefSeq ID
NM_024262
RefSeq Synonyms
NM_024262, BC020005,
Species
mouse
UniGene ID
Mm.23257
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.