human STARD5 shRNA silencing AAV

Name
AAV-h-STARD5-shRNA

Cat No
shAAV-224523

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human STARD5.

shAAV-224523

AAV-h-STARD5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human STARD5 (StAR related lipid transfer domain containing 5). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002 (PubMed 12011452)).(supplied by OMIM, Mar 2008)

Gene ID

80765

Gene Name (Vector)

StAR related lipid transfer domain containing 5

Gene Symbol

STARD5

HGNC ID

HGNC:18065

ORF Size (aa)

642

ORF Size (bp)

642 bp

RefSeq ID

NM_181900

RefSeq Synonyms

NM_181900, BC004365,

Species

human

UniGene ID

Hs.513075

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.