human SCAP shRNA silencing AAV

Name 
AAV-h-SCAP-shRNA
Cat No 
shAAV-222307
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SCAP.

shAAV-222307
AAV-h-SCAP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SCAP (SREBF chaperone). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
SCAP; SREBP cleavage-activating protein; sterol regulatory element-binding protein cleavage-activating protein
Description (eCommerce)
Sterol regulatory element-binding protein cleavage-activating protein (SCAP) is a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, SCAP binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis [taken from NCBI Entrez Gene (Gene ID: 22937)].
Description (Vector)
SCAP encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis.
Gene ID
22937
Gene Name (eCommerce)
SREBF chaperone
Gene Name (Vector)
SREBF chaperone
Gene Symbol
SCAP
HGNC ID
HGNC:30634
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2718
ORF Size (bp)
2718 bp
Protein Name (eCommerce)
Sterol regulatory element-binding protein cleavage-activating protein
RefSeq ID
NM_012235
RefSeq Synonyms
NM_012235, NM_001320044, BC020987,
Research Areas
Aging,Golgi Apparatus,Hypoxia,Metabolism/Metabolic Process,Protein Folding,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,metabolism,cell_biology
Species
human
Target Sentence
Sterol regulatory element-binding protein cleavage-activating protein (SCAP) is a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, SCAP binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis [taken from NCBI Entrez Gene (Gene ID: 22937)].
UniGene ID
Hs.531789
UniProt ID (eCommerce)
Q12770

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.