human PQBP1 shRNA silencing AAV

Name 
AAV-h-PQBP1-shRNA
Cat No 
shAAV-219702
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PQBP1.

shAAV-219702
AAV-h-PQBP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PQBP1 (polyglutamine binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
38 kDa nuclear protein containing a WW domain; MRX2; MRX55; MRXS3; MRXS8; NPW38; polyglutamine tract-binding protein 1; polyglutamine-binding protein 1; PQBP-1; RENS1; SHS
Description (eCommerce)
Polyglutamine-binding protein 1 (PQBP1) is a nuclear polyglutamine-binding protein that is involved with transcriptional activation. Mutations in the PQBP1 gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation [taken from NCBI Entrez Gene (Gene ID: 10084].
Description (Vector)
PQBP1 encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Gene ID
10084
Gene Name (eCommerce)
polyglutamine binding protein 1
Gene Name (Vector)
polyglutamine binding protein 1
Gene Symbol
PQBP1
HGNC ID
HGNC:9330
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
798
Protein Name (eCommerce)
Polyglutamine-binding protein 1
RefSeq ID
NM_005710
RefSeq Synonyms
NM_144495, NM_005710, NM_001167992, NM_001167990, NM_001167989, NM_001032384, NM_001032383, NM_001032382, NM_001032381, BC012358,
Research Areas
Gene Expression,Neurobiology,RNA Processing,Spliceosome,Transcription Factor/Regulator
Research Areas (Faceted)
genetics,transcription_translation,neurobiology,cell_biology
Species
human
Target Sentence
Polyglutamine-binding protein 1 (PQBP1) is a nuclear polyglutamine-binding protein that is involved with transcriptional activation. Mutations in the PQBP1 gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation [taken from NCBI Entrez Gene (Gene ID: 10084].
UniGene ID
Hs.534384
UniProt ID (eCommerce)
O60828

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.