human PPFIA2 shRNA silencing AAV

Name
AAV-h-PPFIA2-shRNA

Cat No
shAAV-219526

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PPFIA2.

shAAV-219526

AAV-h-PPFIA2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PPFIA2 (PTPRF interacting protein alpha 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

PPFIA2 is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein is most closely related to PPFIA1, a liprin family member known to interact with the protein phosphatase LAR. The expression of this gene is found to be downregulated by androgens in a prostate cancer cell line. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

8499

Gene Name (Vector)

PTPRF interacting protein alpha 2

Gene Symbol

PPFIA2

HGNC ID

HGNC:9246

ORF Size (aa)

3756

ORF Size (bp)

3756 bp

RefSeq ID

NM_003625

RefSeq Synonyms

NM_003625, NM_001282536, NM_001220480, NM_001220479, NM_001220478, NM_001220477, NM_001220476, NM_001220475, NM_001220474, NM_001220473, BC143485, BC104912,

Species

human

UniGene ID

Hs.506216

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.