human NR3C2 shRNA silencing AAV

Name
AAV-h-NR3C2-shRNA

Cat No
shAAV-217055

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NR3C2.

shAAV-217055

AAV-h-NR3C2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NR3C2 (nuclear receptor subfamily 3 group C member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MCR; MLR; MR; NR3C2VIT

Description (Vector)

NR3C2 encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.

Gene ID

4306

Gene Name (Vector)

nuclear receptor subfamily 3 group C member 2

Gene Symbol

NR3C2

HGNC ID

HGNC:7979

ORF Size (aa)

2604

ORF Size (bp)

2604 bp

RefSeq ID

NM_000901

RefSeq Synonyms

NM_001166104, NM_000901, BC111758,

Species

human

UniGene ID

Hs.163924

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.