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human N4BP1 shRNA silencing AAV

Name 
AAV-h-N4BP1-shRNA
Cat No 
shAAV-216262
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human N4BP1.

shAAV-216262
AAV-h-N4BP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human N4BP1 (NEDD4 binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
N4BP1; NEDD4-binding protein 1
Description (eCommerce)
N4BP1 is an inhibitor of the E3 ubiquitin-protein ligase ITCH. N4BP1 ccts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75113].
Gene ID
9683
Gene Name (eCommerce)
NEDD4 binding protein 1
Gene Name (Vector)
NEDD4 binding protein 1
Gene Symbol
N4BP1
HGNC ID
HGNC:29850
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2691
ORF Size (bp)
2691 bp
Protein Name (eCommerce)
NEDD4-binding protein 1
RefSeq ID
NM_153029
RefSeq Synonyms
NM_153029, BC160019, BC152472,
Research Areas
Ubiquitination
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
N4BP1 is an inhibitor of the E3 ubiquitin-protein ligase ITCH. N4BP1 ccts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75113].
UniGene ID
Hs.511839
UniProt ID (eCommerce)
O75113

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.