human MSH2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MSH2.
shAAV-215905
AAV-h-MSH2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MSH2 (mutS homolog 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
COCA1; DNA mismatch repair protein Msh2; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2
Description (eCommerce)
MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC).
Description (Vector)
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
4436
Gene Name (eCommerce)
mutS homolog 2
Gene Name (Vector)
mutS homolog 2
Gene Symbol
MSH2
HGNC ID
HGNC:7325
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2805
ORF Size (bp)
2805 bp
Protein Name (eCommerce)
DNA mismatch repair protein Msh2
RefSeq ID
NM_000251
RefSeq Synonyms
NM_001258281, NM_000251, BC021566,
Research Areas
Apoptosis,Breast Cancer,Cancer,Cell Cycle,Colorectal Cancer,DNA Damage/Repair,Helicase Activity,Immunology,Neurobiology,Neurodevelopment,Prostate Cancer,Spermatogenesis,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,immunology,neurobiology,developmental_biology,cell_biology,cell_cycle,cancer,transcription_translation
Species
human
Target Sentence
MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC).
UniGene ID
Hs.597656
UniProt ID (eCommerce)
P43246
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.