human LDLR shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-213796
Availability:
4-5 weeks
Name:
AAV-h-LDLR-shRNA
This is an AAV expressing shRNA for silencing of Human LDLR.
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Product Info
- Knockdown
- >80% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- LDLR
- Gene Name
- low density lipoprotein receptor
- Gene ID
- 3949
- Gene Synonyms
- FH; FHC; LDLCQ2
- ORF Size
- 2583 bp
- RefSeq#
- NM_000527
- Gene Description
- The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
- UniGene ID
- Hs.713967
- HGNC ID
- HGNC:6547
Related Products
Product | Cat No. |
---|---|
AAV-h-LDLR | AAV-213796 |
AAV-m-LDLR | AAV-263355 |
Ad-h-LDLR | ADV-213796 |
Ad-m-LDLR | ADV-263355 |
AAV-m-LDLR-shRNA | shAAV-263355 |
Ad-h-LDLR-shRNA | shADV-213796 |
Ad-m-LDLR-shRNA | shADV-263355 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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