human KDM5B shRNA silencing AAV

Name 
AAV-h-KDM5B-shRNA
Cat No 
shAAV-212852
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KDM5B.

shAAV-212852
AAV-h-KDM5B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KDM5B (lysine demethylase 5B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
cancer/testis antigen 31; CT31; histone demethylase JARID1B; JARID1B; jumonji, AT rich interactive domain 1B; jumonji/ARID domain-containing protein 1B; lysine (K)-specific demethylase 5B; lysine-specific demethylase 5B; MRT65; PLU1; PLU-1; PPP1R98; protein phosphatase 1, regulatory subunit 98; PUT1; putative DNA/chromatin binding motif; RBBP2H1A; RBP2-H1; retinoblastoma-binding protein 2 homolog 1; retinoblastoma-binding protein 2, homolog 1A
Description (eCommerce)
JARID1B (Jumonji AT-rich interactive domain 1B) is a member of the JARID 1 family of proteins that catalyze the demethylation of histones on lysine. The Jarid 1 family members include JARID1A, JARID1B, JARID1C and JARID1D. The members of this family possess a Jumonji C (JmjC) and Jumonji N (JmjN) domain as well as one ARID (AT-rich interactive domain) and three PHD-type zinc fingers. As histone demethylases, JARID 1 proteins function as transcriptional repressors. JARID1B expression is largely restricted to testis and may play a critical role in tumorigenesis as it has been found to be upregulated in prostate and breast cancer.
Gene ID
10765
Gene Name (eCommerce)
lysine demethylase 5B
Gene Name (Vector)
lysine demethylase 5B
Gene Symbol
KDM5B
HGNC ID
HGNC:18039
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4635
ORF Size (bp)
4635 bp
Protein Name (eCommerce)
Lysine-specific demethylase 5B
RefSeq ID
NM_006618
RefSeq Synonyms
NM_006618, NM_001347591, NM_001314042, BC157031, BC156049,
Research Areas
Cancer,Chromatin Remodeling,Histone Modification,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
JARID1B (Jumonji AT-rich interactive domain 1B) is a member of the JARID 1 family of proteins that catalyze the demethylation of histones on lysine. The Jarid 1 family members include JARID1A, JARID1B, JARID1C and JARID1D. The members of this family possess a Jumonji C (JmjC) and Jumonji N (JmjN) domain as well as one ARID (AT-rich interactive domain) and three PHD-type zinc fingers. As histone demethylases, JARID 1 proteins function as transcriptional repressors. JARID1B expression is largely restricted to testis and may play a critical role in tumorigenesis as it has been found to be upregulated in prostate and breast cancer.
UniGene ID
Hs.443650
UniProt ID (eCommerce)
Q9UGL1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.