human IMPDH1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human IMPDH1.
shAAV-212245
AAV-h-IMPDH1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human IMPDH1 (inosine monophosphate dehydrogenase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IMPD; IMPD1; IMPDH-I; LCA11; RP10; sWSS2608
Description (Vector)
IMPDH1 acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
3614
Gene Name (Vector)
inosine monophosphate dehydrogenase 1
Gene Symbol
IMPDH1
HGNC ID
HGNC:6052
ORF Size (aa)
1692
ORF Size (bp)
1692 bp
RefSeq ID
NM_183243
RefSeq Synonyms
NM_183243, NM_001304521, NM_001142576, NM_001142575, NM_001142574, NM_001142573, NM_001102605, NM_000883, BC033622,
Species
human
UniGene ID
Hs.654401
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.