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human INTS3 shRNA silencing AAV

Name 
AAV-h-INTS3-shRNA
Cat No 
shAAV-212318
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human INTS3.

shAAV-212318
AAV-h-INTS3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human INTS3 (integrator complex subunit 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C1orf193; C1orf60; INT3; integrator complex subunit 3; sensor of single-strand DNA complex subunit A; sensor of ssDNA subunit A; SOSS complex subunit A; SOSSA; SOSS-A
Description (eCommerce)
Integrator complex subunit 3 (Int3) is a subunit of the integrator complex which associates with the C-terminal domain of the RNA polymerase II large subunit involved in the processing of small nuclear RNAs U1.
Description (Vector)
INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)). INTS3 is also a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) (PubMed 19683501).(supplied by OMIM, Feb 2010)
Gene ID
65123
Gene Name (eCommerce)
integrator complex subunit 3
Gene Name (Vector)
integrator complex subunit 3
Gene Symbol
INTS3
HGNC ID
HGNC:26153
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3129
ORF Size (bp)
3129 bp
Protein Name (eCommerce)
Integrator complex subunit 3
RefSeq ID
NM_023015
RefSeq Synonyms
NM_023015, NM_001324475, BC116458, BC105094, BC105092,
Research Areas
Cell Cycle,DNA Damage/Repair,RNA Processing
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Integrator complex subunit 3 (Int3) is a subunit of the integrator complex which associates with the C-terminal domain of the RNA polymerase II large subunit involved in the processing of small nuclear RNAs U1.
UniGene ID
Hs.516522
UniProt ID (eCommerce)
Q68E01

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.