human IL28B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human IFNL3.
shAAV-212167
AAV-h-IL28B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human IFNL3 (interferon lambda 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IFN-lambda-3; IFN-lambda-4; IL-28B; IL-28C; IL28B; IL28C
Description (Vector)
IL28B encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
Gene ID
282617
Gene Name (Vector)
interferon lambda 3
Gene Symbol
IFNL3
HGNC ID
HGNC:18365
ORF Size (aa)
591
RefSeq ID
NM_172139
RefSeq Synonyms
NM_172139, NM_001346937, BC130316, BC130314,
Species
human
UniGene ID
Hs.406744
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.