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human SETDB1 Adenovirus

Name 
Ad-h-SETDB1
Cat No 
ADV-222742
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human SETDB1.

ADV-222742
Ad-h-SETDB1

Ready-to-use Adenovirus expressing Human SETDB1 (SET domain bifurcated 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ERG-associated protein with a SET domain, ESET; ERG-associated protein with SET domain; ESET; H3-K9-HMTase 4; H3-K9-HMTase4; histone H3-K9 methyltransferase 4; histone-lysine N-methyltransferase SETDB1; histone-lysine N-methyltransferase, H3lysine-9 specific 4; KG1T; KMT1E; lysine N-methyltransferase 1E; SET domain bifurcated 1; TDRD21; tudor domain containing 21
Description (eCommerce)
SETDB1 (SET domain, bifurcated 1) is a member of the SET (SuVar3-9, enhancer of Zeste, Trithorax) domain-containing protein family that functions as a histone and DNA methyltransferase. SETDB1 was identified through its interaction with ERG (ets-related gene) and KAP1 (KRAB-associated protein1) and was later demonstrated to interact with HDAC1/2 (histone deacetylase 1/2), DNA methyltransferase 3s (DNMT3s), mSin3A/3B, HP1, and MBD1. SETDB1 is suggested to play a role in transcriptional repression important to early development.
Description (Vector)
SETDB1 encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. SETDB1 has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.
Gene ID
9869
Gene Name (eCommerce)
SET domain bifurcated 1
Gene Name (Vector)
SET domain bifurcated 1
Gene Symbol
SETDB1
HGNC ID
HGNC:10761
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3873
ORF Size (bp)
3873 bp
Protein Name (eCommerce)
Histone-lysine N-methyltransferase SETDB1
RefSeq ID
NM_012432
RefSeq Synonyms
NM_012432, NM_001243491, NM_001145415, BC028671, BC009362,
Research Areas
Chromatin Remodeling,Golgi Apparatus,Histone Modification,Methyltransferase,Neurobiology,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cell_biology,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
SETDB1 (SET domain, bifurcated 1) is a member of the SET (SuVar3-9, enhancer of Zeste, Trithorax) domain-containing protein family that functions as a histone and DNA methyltransferase. SETDB1 was identified through its interaction with ERG (ets-related gene) and KAP1 (KRAB-associated protein1) and was later demonstrated to interact with HDAC1/2 (histone deacetylase 1/2), DNA methyltransferase 3s (DNMT3s), mSin3A/3B, HP1, and MBD1. SETDB1 is suggested to play a role in transcriptional repression important to early development.
UniGene ID
Hs.643565
UniProt ID (eCommerce)
Q15047

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.