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human IL7R shRNA silencing AAV

Name 
AAV-h-IL7R-shRNA
Cat No 
shAAV-212207
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human IL7R.

shAAV-212207
AAV-h-IL7R-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IL7R (interleukin 7 receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD127; CD127; CD127 antigen; CDW127; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL7RA; IL-7RA; IL-7R-alpha; ILRA; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; interleukin-7 receptor subunit alpha
Description (eCommerce)
CD127/IL-7R alpha is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. IL7 is a hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. [taken from NCBI Entrez Gene (Gene ID: 3575)].
Description (Vector)
IL7R is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
Gene ID
3575
Gene Name (eCommerce)
interleukin 7 receptor
Gene Name (Vector)
interleukin 7 receptor
Gene Symbol
IL7R
HGNC ID
HGNC:6024
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1380
ORF Size (bp)
1380 bp
Protein Name (eCommerce)
Interleukin-7 receptor subunit alpha
RefSeq ID
NM_002185
RefSeq Synonyms
NM_002185, BC069999, BC067540, BC067539, BC067538, BC067537,
Research Areas
Cytokine Signaling,Gene Expression,Immunology,Interleukin Signaling,JAK-STAT Signaling,PI3K/Akt Signaling,SCF-KIT Signaling,Signal Transduction,TSLP Signaling
Research Areas (Faceted)
cell_biology,immunology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
CD127/IL-7R alpha is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. IL7 is a hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. [taken from NCBI Entrez Gene (Gene ID: 3575)].
UniGene ID
Hs.635723
UniProt ID (eCommerce)
P16871

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.