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human EIF3A shRNA silencing AAV

Name 
AAV-h-EIF3A-shRNA
Cat No 
shAAV-207731
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human EIF3A.

shAAV-207731
AAV-h-EIF3A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EIF3A (eukaryotic translation initiation factor 3 subunit A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
centrosomin homolog; cytoplasmic protein p167; EIF3; eIF3 p167; eIF3 p180; eIF3 p185; EIF3, p180 subunit; eIF3a; eIF3-p170; EIF3S10; eIF-3-theta; eIF3-theta; eukaryotic translation initiation factor 3 subunit 10; eukaryotic translation initiation factor 3 subunit A; eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD); eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD); eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa; eukaryotic translation initiation factor 3, subunit 10, 170kD; P167; p180; p185; TIF32
Description (eCommerce)
Eukaryotic initiation factor 3 subunit A (eIF3A) is one of at least 13 non-identical protein subunits of eukaryotic initiation factor 3 (eIF3). eIF3 is the largest eIF (~650 kDa) and functions to facilitate binding of the 40S ribosomal subunit to the 5’-end of cellular mRNAs near the cap structure (m7GpppN). eIF3A is also known as EIF3S10 (eukaryotic initiation factor 3 subunit 7). eIF3A is the largest subunit of the eIF3 complex. eIF3A expression is regulated through the cell cycle. It’s expression peaks in S-phase and it is proposed to play a role in regulating the translation of mRNAs involved in the regulation of cell cycle progression and proliferation.
Gene ID
8661
Gene Name (eCommerce)
eukaryotic translation initiation factor 3 subunit A
Gene Name (Vector)
eukaryotic translation initiation factor 3 subunit A
Gene Symbol
EIF3A
HGNC ID
HGNC:3271
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4149
ORF Size (bp)
4149 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 3 subunit A
RefSeq ID
NM_003750
RefSeq Synonyms
NM_003750, BC114429,
Research Areas
Cell Cycle,Cell Division,Gene Expression,Metabolism/Metabolic Process,mRNA Binding,mTOR Signaling,RNA Transport,Signal Transduction,Translational Control
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,metabolism,genetics,signal_transduction,metabolism,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Eukaryotic initiation factor 3 subunit A (eIF3A) is one of at least 13 non-identical protein subunits of eukaryotic initiation factor 3 (eIF3). eIF3 is the largest eIF (~650 kDa) and functions to facilitate binding of the 40S ribosomal subunit to the 5’-end of cellular mRNAs near the cap structure (m7GpppN). eIF3A is also known as EIF3S10 (eukaryotic initiation factor 3 subunit 7). eIF3A is the largest subunit of the eIF3 complex. eIF3A expression is regulated through the cell cycle. It’s expression peaks in S-phase and it is proposed to play a role in regulating the translation of mRNAs involved in the regulation of cell cycle progression and proliferation.
UniGene ID
Hs.523299
UniProt ID (eCommerce)
Q14152

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.