human CDKN2C shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CDKN2C.
shAAV-204884
AAV-h-CDKN2C-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CDKN2C (cyclin dependent kinase inhibitor 2C). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
INK4C; p18; p18-INK4C
Description (Vector)
CDKN2C is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
Gene ID
1031
Gene Name (Vector)
cyclin dependent kinase inhibitor 2C
Gene Symbol
CDKN2C
HGNC ID
HGNC:1789
ORF Size (aa)
507
ORF Size (bp)
507 bp
RefSeq ID
NM_001262
RefSeq Synonyms
NM_078626, NM_001262, BC016173, BC005041, BC000598,
Species
human
UniGene ID
Hs.716664
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.