human BOP1 shRNA silencing AAV

Name
AAV-h-BOP1-shRNA

Cat No
shAAV-202234

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human BOP1.

shAAV-202234

AAV-h-BOP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BOP1 (block of proliferation 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Block of proliferation 1 protein; ribosome biogenesis protein BOP1

Description (eCommerce)

BOP1 (block of proliferation 1) is a component of the PeBoW (Pes1, Bop, WDR12) complex that plays a role in the processing of 28S and 5.8S ribosomal RNAs and the formation of the 60S ribosome. BOP1 contains seven WD repeats and was originally identified as a cDNA which inhibited cell proliferation. The deregulation of the BOP1 gene is proposed to contribute to colorectal tumorigenesis.

Gene ID

23246

Gene Name (eCommerce)

block of proliferation 1

Gene Name (Vector)

block of proliferation 1

Gene Symbol

BOP1

HGNC ID

HGNC:15519

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2241

ORF Size (bp)

2241 bp

Protein Name (eCommerce)

Ribosome biogenesis protein BOP1

RefSeq ID

NM_015201

RefSeq Synonyms

NM_015201, BC017674, BC013980, BC013787,

Research Areas

Cell Cycle,RNA Processing

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,transcription_translation

Species

human

Target Sentence

BOP1 (block of proliferation 1) is a component of the PeBoW (Pes1, Bop, WDR12) complex that plays a role in the processing of 28S and 5.8S ribosomal RNAs and the formation of the 60S ribosome. BOP1 contains seven WD repeats and was originally identified as a cDNA which inhibited cell proliferation. The deregulation of the BOP1 gene is proposed to contribute to colorectal tumorigenesis.

UniGene ID

Hs.645279

UniProt ID (eCommerce)

Q14137

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.