human MED24 Adenovirus

Name
Ad-h-MED24

Cat No
ADV-215257

Availability
4-5 weeks

This is an Adenovirus expressing Human MED24.

ADV-215257

Ad-h-MED24

Ready-to-use Adenovirus expressing Human MED24 (mediator complex subunit 24). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

activator-recruited cofactor 100 kDa component; ARC100; cofactor required for Sp1 transcriptional activation subunit 4; cofactor required for Sp1 transcriptional activation, subunit 4, 100kDa; CRSP complex subunit 4; CRSP100; CRSP4; DRIP100; hTRAP100; MED5; Mediator complex subunit 24; mediator of RNA polymerase II transcription subunit 24; mediator of RNA polymerase II transcription, subunit 24 homolog; THRAP4; thyroid hormone receptor-associated protein 4; thyroid hormone receptor-associated protein complex 100 kDa component; TRAP100; vitamin D3 receptor-interacting protein complex 100 kDa component; vitamin D3 receptor-interacting protein complex component DRIP100

Description (eCommerce)

TRAP100/MED24 is a component of the multisubunit mediator complex that functions as an interface between gene-specific transcription factors and the RNA Pol II/general transcription factor machinery. The mediator complex was first identified as a coactivator of the thyroid hormone receptor and has since been observed to function as a coactivator of a variety of transcription factors. TRAP100/MED24 associates with mediator subunit TRAP220. Both are essential to mouse development and play a role in androgen receptor-mediated transcription. Studies in zebrafish have shown that TRAP100/MED24 is also important to retinal development.

Description (Vector)

MED24 encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

9862

Gene Name (eCommerce)

mediator complex subunit 24

Gene Name (Vector)

mediator complex subunit 24

Gene Symbol

MED24

HGNC ID

HGNC:22963

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2970

ORF Size (bp)

2970 bp

Protein Name (eCommerce)

Mediator of RNA polymerase II transcription subunit 24

RefSeq ID

NM_014815

RefSeq Synonyms

NM_014815, NM_001330211, NM_001267797, NM_001079518, BC011375,

Research Areas

Gene Expression,Metabolism/Metabolic Process,Nuclear Receptor Coactivators,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,metabolism,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.462983

UniProt ID (eCommerce)

O75448

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.