mouse EPHB3 shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-258580
Availability:
4-5 weeks
Name:
AAV-m-EPHB3-shRNA
This is an AAV expressing shRNA for silencing of Mouse Ephb3.
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Product Info
- Knockdown
- >50% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Ephb3
- Gene Name
- Eph receptor B3
- Gene ID
- 13845
- Gene Synonyms
- AW456895; Cek10; Etk2; HEK2; MDK5; Sek4; Tyro6
- ORF Size
- 2982 bp
- RefSeq#
- NM_010143
- Gene Description
- Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobs of the cerebral cortex. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.
- UniGene ID
- Mm.6972
Related Products
Product | Cat No. |
---|---|
AAV-h-EPHB3 | AAV-207995 |
AAV-m-EPHB3 | AAV-258580 |
Ad-h-EPHB3 | ADV-207995 |
Ad-m-EPHB3 | ADV-258580 |
AAV-h-EPHB3-shRNA | shAAV-207995 |
Ad-h-EPHB3-shRNA | shADV-207995 |
Ad-m-EPHB3-shRNA | shADV-258580 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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