rat INSIG2 Over-expression AAV
This is an AAV expressing Rat Insig2.
AAV-293762
AAV-r-INSIG2
Ready-to-use AAV expressing Rat Insig2 (insulin induced gene 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.
Gene ID
288985
Gene Name (Vector)
insulin induced gene 2
Gene Symbol
Insig2
ORF Size (aa)
678
RefSeq ID
NM_178091
RefSeq Synonyms
NM_178091, BC085682,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.