mouse INSIG2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Insig2.
shADV-262278
Ad-m-INSIG2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Insig2 (insulin induced gene 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2900053I11Rik; C730043J18Rik; Insig-2
Description (Vector)
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.
Gene ID
72999
Gene Name (Vector)
insulin induced gene 2
Gene Symbol
Insig2
ORF Size (aa)
678
RefSeq ID
NM_133748
RefSeq Synonyms
NM_178082, NM_133748, NM_001271532, NM_001271531, BC024411, BC023874, BC023067, BC015288,
Species
mouse
UniGene ID
Mm.27136
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.