mouse USP14 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-281194
Availability:
3-5 weeks
Name:
AAV-m-USP14
This is an AAV expressing Mouse Usp14.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Usp14
- Gene Name
- ubiquitin specific peptidase 14
- Gene ID
- 59025
- Gene Synonyms
- 2610005K12Rik; 2610037B11Rik; AW107924; ax; C78769; nmf375
- ORF Size
- 1377 bp
- RefSeq#
- BC050197
- Gene Description
- Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
- UniGene ID
- Mm.447089
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