mouse UBR2 Over-expression AAV

Name 
AAV-m-UBR2
Cat No 
AAV-275543
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Ubr2.

AAV-275543
AAV-m-UBR2

Ready-to-use AAV expressing Mouse Ubr2 (ubiquitin protein ligase E3 component n-recognin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
9930021A08Rik; AI462103; AW540746; E130209G04Rik; ENSMUSG00000043296; mKIAA0349
Description (Vector)
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Gene ID
224826
Gene Name (Vector)
ubiquitin protein ligase E3 component n-recognin 2
Gene Symbol
Ubr2
ORF Size (aa)
5268
ORF Size (bp)
5268 bp
RefSeq ID
NM_146078
RefSeq Synonyms
NM_146078, NM_001177374, BC075642, BC031403,
Species
mouse
UniGene ID
Mm.28234

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.