human MDM2 Over-expression AAV

Name 
AAV-h-MDM2
Cat No 
AAV-231762
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MDM2.

AAV-231762
AAV-h-MDM2

Ready-to-use AAV expressing Human MDM2 (MDM2 proto-oncogene). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ACTFS; hdm2; HDMX
Description (Vector)
MDM2 is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
Gene ID
4193
Gene Name (Vector)
MDM2 proto-oncogene
Gene Symbol
MDM2
HGNC ID
HGNC:6973
ORF Size (aa)
1491
ORF Size (bp)
1491 bp
RefSeq ID
NM_002392
RefSeq Synonyms
NM_002392, NM_001278462, NM_001145340, NM_001145339, NM_001145337, BC153117, BC148522,
Species
human
UniGene ID
Hs.484551

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.