human MDM2 shRNA silencing AAV

Name
AAV-h-MDM2-shRNA

Cat No
shAAV-230831

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human MDM2.

shAAV-230831

AAV-h-MDM2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MDM2 (MDM2 proto-oncogene). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACTFS; hdm2; HDMX

Description (Vector)

MDM2 is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Gene ID

4193

Gene Name (Vector)

MDM2 proto-oncogene

Gene Symbol

MDM2

HGNC ID

HGNC:6973

ORF Size (aa)

1491

ORF Size (bp)

1491 bp

RefSeq ID

NM_002392

RefSeq Synonyms

NM_002392, NM_001278462, NM_001145340, NM_001145339, NM_001145337, BC153117, BC148522,

Species

human

UniGene ID

Hs.484551

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.