human ZC3H8 Over-expression AAV

Name 
AAV-h-ZC3H8
Cat No 
AAV-228104
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ZC3H8.

AAV-228104
AAV-h-ZC3H8

Ready-to-use AAV expressing Human ZC3H8 (zinc finger CCCH-type containing 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Fliz1; ZC3HDC8; zinc finger CCCH domain-containing protein 8; zinc finger CCCH-type domain containing 8
Description (eCommerce)
Zinc-finger CCCH domain-containing protein 8 (ZC3H8) acts as a transcriptional repressor of the GATA3 promoter. It is a sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (by similarity). ZC3H8 induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8N5P1].
Gene ID
84524
Gene Name (eCommerce)
zinc finger CCCH-type containing 8
Gene Name (Vector)
zinc finger CCCH-type containing 8
Gene Symbol
ZC3H8
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
894
ORF Size (bp)
894 bp
Protein Name (eCommerce)
Zinc finger CCCH domain-containing protein 8
RefSeq ID
NM_032494
RefSeq Synonyms
NM_032494, BC032001,
Research Areas
Apoptosis,Immunology,RNA Binding,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,transcription_translation
Species
human
Target Sentence
Zinc-finger CCCH domain-containing protein 8 (ZC3H8) acts as a transcriptional repressor of the GATA3 promoter. It is a sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (by similarity). ZC3H8 induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8N5P1].
UniGene ID
Hs.418416
UniProt ID (eCommerce)
Q8N5P1

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.