human ZC3H8 shRNA silencing Adenovirus

Name
Ad-h-ZC3H8-shRNA

Cat No
shADV-228104

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human ZC3H8.

shADV-228104

Ad-h-ZC3H8-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ZC3H8 (zinc finger CCCH-type containing 8). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Fliz1; ZC3HDC8; zinc finger CCCH domain-containing protein 8; zinc finger CCCH-type domain containing 8

Description (eCommerce)

Zinc-finger CCCH domain-containing protein 8 (ZC3H8) acts as a transcriptional repressor of the GATA3 promoter. It is a sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (by similarity). ZC3H8 induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8N5P1].

Gene ID

84524

Gene Name (eCommerce)

zinc finger CCCH-type containing 8

Gene Name (Vector)

zinc finger CCCH-type containing 8

Gene Symbol

ZC3H8

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

894

ORF Size (bp)

894 bp

Protein Name (eCommerce)

Zinc finger CCCH domain-containing protein 8

RefSeq ID

NM_032494

RefSeq Synonyms

NM_032494, BC032001,

Research Areas

Apoptosis,Immunology,RNA Binding,Transcription Factor/Regulator,Zinc-finger

Research Areas (Faceted)

cell_biology,immunology,transcription_translation

Species

human

Target Sentence

Zinc-finger CCCH domain-containing protein 8 (ZC3H8) acts as a transcriptional repressor of the GATA3 promoter. It is a sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (by similarity). ZC3H8 induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8N5P1].

UniGene ID

Hs.418416

UniProt ID (eCommerce)

Q8N5P1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.