human TMEM123 Over-expression AAV

Name 
AAV-h-TMEM123
Cat No 
AAV-225722
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TMEM123.

AAV-225722
AAV-h-TMEM123

Ready-to-use AAV expressing Human TMEM123 (transmembrane protein 123). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
KCT3; PORIMIN; PORMIN
Description (Vector)
TMEM123 encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. TMEM123 product is proposed to function as a cell surface receptor that mediates cell death.
Gene ID
114908
Gene Name (Vector)
transmembrane protein 123
Gene Symbol
TMEM123
HGNC ID
HGNC:30138
ORF Size (aa)
627
RefSeq ID
NM_052932
RefSeq Synonyms
NM_052932, BC032296,
Species
human
UniGene ID
Hs.707514

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.