human TMEM123 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TMEM123.
shADV-225722
Ad-h-TMEM123-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TMEM123 (transmembrane protein 123). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
KCT3; PORIMIN; PORMIN
Description (Vector)
TMEM123 encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. TMEM123 product is proposed to function as a cell surface receptor that mediates cell death.
Gene ID
114908
Gene Name (Vector)
transmembrane protein 123
Gene Symbol
TMEM123
HGNC ID
HGNC:30138
ORF Size (aa)
627
RefSeq ID
NM_052932
RefSeq Synonyms
NM_052932, BC032296,
Species
human
UniGene ID
Hs.707514
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.