human TBX3 Over-expression AAV

Name 
AAV-h-TBX3
Cat No 
AAV-225160
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TBX3.

AAV-225160
AAV-h-TBX3

Ready-to-use AAV expressing Human TBX3 (T-box 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bladder cancer related protein XHL; T-box protein 3; T-box transcription factor TBX3; TBX3-ISO; UMS; XHL
Description (eCommerce)
T-box protein 3 (TBX3) is a transcriptional repressor involved in developmental processes. TBX3 probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O15119].
Description (Vector)
TBX3 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.
Gene ID
6926
Gene Name (eCommerce)
T-box 3
Gene Name (Vector)
T-box 3
Gene Symbol
TBX3
HGNC ID
HGNC:11602
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2232
ORF Size (bp)
2232 bp
Protein Name (eCommerce)
T-box transcription factor TBX3
RefSeq ID
NM_016569
RefSeq Synonyms
NM_016569, NM_005996, BC025258,
Research Areas
Aging,Apoptosis,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,RNA Binding,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation
Species
human
Target Sentence
T-box protein 3 (TBX3) is a transcriptional repressor involved in developmental processes. TBX3 probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O15119].
UniGene ID
Hs.714737
UniProt ID (eCommerce)
O15119

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.