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human TBX3 shRNA silencing Adenovirus

Name 
Ad-h-TBX3-shRNA
Cat No 
shADV-225160
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TBX3.

shADV-225160
Ad-h-TBX3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TBX3 (T-box 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
bladder cancer related protein XHL; T-box protein 3; T-box transcription factor TBX3; TBX3-ISO; UMS; XHL
Description (eCommerce)
T-box protein 3 (TBX3) is a transcriptional repressor involved in developmental processes. TBX3 probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O15119].
Description (Vector)
TBX3 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.
Gene ID
6926
Gene Name (eCommerce)
T-box 3
Gene Name (Vector)
T-box 3
Gene Symbol
TBX3
HGNC ID
HGNC:11602
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2232
ORF Size (bp)
2232 bp
Protein Name (eCommerce)
T-box transcription factor TBX3
RefSeq ID
NM_016569
RefSeq Synonyms
NM_016569, NM_005996, BC025258,
Research Areas
Aging,Apoptosis,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,RNA Binding,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation
Species
human
Target Sentence
T-box protein 3 (TBX3) is a transcriptional repressor involved in developmental processes. TBX3 probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O15119].
UniGene ID
Hs.714737
UniProt ID (eCommerce)
O15119

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.