human SPOP Over-expression AAV

Name 
AAV-h-SPOP
Cat No 
AAV-224227
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SPOP.

AAV-224227
AAV-h-SPOP

Ready-to-use AAV expressing Human SPOP (speckle type BTB/POZ protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BTBD32; TEF2
Description (Vector)
SPOP encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
Gene ID
8405
Gene Name (Vector)
speckle type BTB/POZ protein
Gene Symbol
SPOP
HGNC ID
HGNC:11254
ORF Size (aa)
1125
ORF Size (bp)
1125 bp
RefSeq ID
NM_003563
RefSeq Synonyms
NM_003563, NM_001007230, NM_001007229, NM_001007228, NM_001007227, NM_001007226, BC003385, BC001269,
Species
human
UniGene ID
Hs.718421

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.