human SERPINB8 Over-expression AAV

Name 
AAV-h-SERPINB8
Cat No 
AAV-222700
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SERPINB8.

AAV-222700
AAV-h-SERPINB8

Ready-to-use AAV expressing Human SERPINB8 (serpin family B member 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAP2; PI8; PSS5
Description (Vector)
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 (PubMed 2690952)). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 (PubMed 9268635)).(supplied by OMIM, Jan 2010)
Gene ID
5271
Gene Name (Vector)
serpin family B member 8
Gene Symbol
SERPINB8
HGNC ID
HGNC:8952
ORF Size (aa)
729
RefSeq ID
NM_002640
RefSeq Synonyms
NM_198833, NM_002640, NM_001276490, NM_001031848, BC034528,
Species
human
UniGene ID
Hs.368077

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.