human SERPINB8 shRNA silencing Adenovirus

Name
Ad-h-SERPINB8-shRNA

Cat No
shADV-222700

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human SERPINB8.

shADV-222700

Ad-h-SERPINB8-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SERPINB8 (serpin family B member 8). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CAP2; PI8; PSS5

Description (Vector)

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 (PubMed 2690952)). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 (PubMed 9268635)).(supplied by OMIM, Jan 2010)

Gene ID

5271

Gene Name (Vector)

serpin family B member 8

Gene Symbol

SERPINB8

HGNC ID

HGNC:8952

ORF Size (aa)

729

RefSeq ID

NM_002640

RefSeq Synonyms

NM_198833, NM_002640, NM_001276490, NM_001031848, BC034528,

Species

human

UniGene ID

Hs.368077

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.