human PPME1 Over-expression AAV

Name 
AAV-h-PPME1
Cat No 
AAV-219593
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PPME1.

AAV-219593
AAV-h-PPME1

Ready-to-use AAV expressing Human PPME1 (protein phosphatase methylesterase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
PME-1; protein phosphatase methylesterase 1; testicular secretory protein Li 39
Description (eCommerce)
PPME1 / PME-1 (protein phosphatase methylesterase 1) is a protein phosphatase methylesterase localized to the nucleus. It acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. PPME1 / PME plays a role in malignant glioma progression [taken from NCBI Entrez Gene (Gene ID: 51400)].
Description (Vector)
Protein phosphatase methylesterase-1 catalyzes the demethylation of the protein phosphatase-2A catalytic subunit (PPP2CA; MIM 176915) (Ogris et al., 1999 (PubMed 10318862)).(supplied by OMIM, Mar 2008)
Gene ID
51400
Gene Name (eCommerce)
protein phosphatase methylesterase 1
Gene Name (Vector)
protein phosphatase methylesterase 1
Gene Symbol
PPME1
HGNC ID
HGNC:30178
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1161
ORF Size (bp)
1161 bp
Protein Name (eCommerce)
Protein phosphatase methylesterase 1
RefSeq ID
NM_016147
RefSeq Synonyms
NM_016147, NM_001271593, BC050705, BC003046,
Research Areas
Cell Biology,Phosphatase
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
PPME1 / PME-1 (protein phosphatase methylesterase 1) is a protein phosphatase methylesterase localized to the nucleus. It acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. PPME1 / PME plays a role in malignant glioma progression [taken from NCBI Entrez Gene (Gene ID: 51400)].
UniGene ID
Hs.503251
UniProt ID (eCommerce)
Q9Y570

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.