human PPME1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PPME1.
shAAV-219593
AAV-h-PPME1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PPME1 (protein phosphatase methylesterase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PME-1; protein phosphatase methylesterase 1; testicular secretory protein Li 39
Description (eCommerce)
PPME1 / PME-1 (protein phosphatase methylesterase 1) is a protein phosphatase methylesterase localized to the nucleus. It acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. PPME1 / PME plays a role in malignant glioma progression [taken from NCBI Entrez Gene (Gene ID: 51400)].
Description (Vector)
Protein phosphatase methylesterase-1 catalyzes the demethylation of the protein phosphatase-2A catalytic subunit (PPP2CA; MIM 176915) (Ogris et al., 1999 (PubMed 10318862)).(supplied by OMIM, Mar 2008)
Gene ID
51400
Gene Name (eCommerce)
protein phosphatase methylesterase 1
Gene Name (Vector)
protein phosphatase methylesterase 1
Gene Symbol
PPME1
HGNC ID
HGNC:30178
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1161
ORF Size (bp)
1161 bp
Protein Name (eCommerce)
Protein phosphatase methylesterase 1
RefSeq ID
NM_016147
RefSeq Synonyms
NM_016147, NM_001271593, BC050705, BC003046,
Research Areas
Cell Biology,Phosphatase
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
PPME1 / PME-1 (protein phosphatase methylesterase 1) is a protein phosphatase methylesterase localized to the nucleus. It acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. PPME1 / PME plays a role in malignant glioma progression [taken from NCBI Entrez Gene (Gene ID: 51400)].
UniGene ID
Hs.503251
UniProt ID (eCommerce)
Q9Y570
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.