human MGRN1 Over-expression AAV

Name
AAV-h-MGRN1

Cat No
AAV-215430

Availability
4-5 weeks

This is an AAV expressing Human MGRN1.

AAV-215430

AAV-h-MGRN1

Ready-to-use AAV expressing Human MGRN1 (mahogunin ring finger 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

E3 ubiquitin-protein ligase MGRN1; mahogunin ring finger 1, E3 ubiquitin protein ligase; mahogunin RING finger protein 1; probable E3 ubiquitin-protein ligase MGRN1; RING finger protein 156; RING-type E3 ubiquitin transferase MGRN1; RNF156

Description (eCommerce)

MGRN1 (mahogunin RING finger protein 1) is an E3 ubiquitin-protein ligase that mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. MGRN1 plays a role in the regulation of endosome-to-lysosome trafficking. It impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production but does not promote MC1R ubiquitination [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O60291].

Description (Vector)

Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.(supplied by OMIM, Apr 2004)

Gene ID

23295

Gene Name (eCommerce)

mahogunin ring finger 1

Gene Name (Vector)

mahogunin ring finger 1

Gene Symbol

MGRN1

HGNC ID

HGNC:20254

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1731

ORF Size (bp)

1731 bp

Protein Name (eCommerce)

E3 ubiquitin-protein ligase MGRN1

RefSeq ID

NM_015246

RefSeq Synonyms

NM_015246, NM_001142291, NM_001142290, NM_001142289, BC050389,

Research Areas

Antigen Processing and Presentation,Immunology,Lysosomal Transport,Signal Transduction,Transport,Ubiquitination,Zinc-finger

Research Areas (Faceted)

cell_biology,immunology,signal_transduction

Species

human

Target Sentence

MGRN1 (mahogunin RING finger protein 1) is an E3 ubiquitin-protein ligase that mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. MGRN1 plays a role in the regulation of endosome-to-lysosome trafficking. It impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production but does not promote MC1R ubiquitination [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O60291].

UniGene ID

Hs.526494

UniProt ID (eCommerce)

O60291

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.