human HPS4 Over-expression AAV

Name 
AAV-h-HPS4
Cat No 
AAV-211504
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HPS4.

AAV-211504
AAV-h-HPS4

Ready-to-use AAV expressing Human HPS4 (HPS4, biogenesis of lysosomal organelles complex 3 subunit 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BLOC3S2; Hermansky-Pudlak syndrome 4 protein; LE; light-ear protein homolog
Description (eCommerce)
Hermansky-Pudlak syndrome 4 protein (HPS4) component of biogenesis of lysosome-related organelles complexes (BLOC). BLOC complexes are important for the formation of endosomal-lysosomal organelles such as melanosomes and platelet dense granules. Mutations in the gene result in subtype 4 of Hermansky-Pudlak syndrome, a form of albinism [taken from NCBI Entrez Gene (Gene ID: 89781)].
Description (Vector)
HPS4 encodes a protein component of biogenesis of lysosome-related organelles complexes (BLOC). BLOC complexes are important for the formation of endosomal-lysosomal organelles such as melanosomes and platelet dense granules. Mutations in this gene result in subtype 4 of Hermansky-Pudlak syndrome, a form of albinism. Alternative splicing results in multiple transcript variants.
Gene ID
89781
Gene Name (eCommerce)
HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
Gene Name (Vector)
HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
Gene Symbol
HPS4
HGNC ID
HGNC:15844
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2127
ORF Size (bp)
2127 bp
Protein Name (eCommerce)
Hermansky-Pudlak syndrome 4 protein
RefSeq ID
NM_022081
RefSeq Synonyms
NM_152841, NM_022081, BC065030,
Research Areas
Lysosome
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Hermansky-Pudlak syndrome 4 protein (HPS4) component of biogenesis of lysosome-related organelles complexes (BLOC). BLOC complexes are important for the formation of endosomal-lysosomal organelles such as melanosomes and platelet dense granules. Mutations in the gene result in subtype 4 of Hermansky-Pudlak syndrome, a form of albinism [taken from NCBI Entrez Gene (Gene ID: 89781)].
UniGene ID
Hs.474436
UniProt ID (eCommerce)
Q9NQG7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.