human HMGB3 Over-expression AAV

Name 
AAV-h-HMGB3
Cat No 
AAV-211278
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HMGB3.

AAV-211278
AAV-h-HMGB3

Ready-to-use AAV expressing Human HMGB3 (high mobility group box 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
high mobility group protein 2a; High mobility group protein 4; high mobility group protein B3; high-mobility group (nonhistone chromosomal) protein 4; HMG2A; HMG-2a; HMG4; HMG-4
Description (eCommerce)
High mobility group protein 2a (HMG2a) is a member of the Hmg-box subfamily of proteins that possesses a DNA-binding HmG-box domain. The HMG2a gene is X-linked and its expression is localized to the bone marrow and is a marker for hematopoietic stem cells (HSCs). HMG2a plays a role in cell-fate decisions of HSCs and functions by altering DNA structure to facilitate transcription factor binding.
Description (Vector)
HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 (MIM 163905) and HMG2 (MIM 163906), HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (Wilke et al., 1997 (PubMed 9370291); Nemeth et al., 2006 (PubMed 16945912)).(supplied by OMIM, Mar 2008)
Gene ID
3149
Gene Name (eCommerce)
high mobility group box 3
Gene Name (Vector)
high mobility group box 3
Gene Symbol
HMGB3
HGNC ID
HGNC:5004
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
603
Protein Name (eCommerce)
High mobility group protein B3
RefSeq ID
NM_005342
RefSeq Synonyms
NM_005342, NM_001301231, NM_001301229, NM_001301228, BC070482,
Research Areas
Chromatin Remodeling,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
High mobility group protein 2a (HMG2a) is a member of the Hmg-box subfamily of proteins that possesses a DNA-binding HmG-box domain. The HMG2a gene is X-linked and its expression is localized to the bone marrow and is a marker for hematopoietic stem cells (HSCs). HMG2a plays a role in cell-fate decisions of HSCs and functions by altering DNA structure to facilitate transcription factor binding.
UniGene ID
Hs.19114
UniProt ID (eCommerce)
O15347

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.