human HMGB3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human HMGB3.
shADV-211278
Ad-h-HMGB3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human HMGB3 (high mobility group box 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
high mobility group protein 2a; High mobility group protein 4; high mobility group protein B3; high-mobility group (nonhistone chromosomal) protein 4; HMG2A; HMG-2a; HMG4; HMG-4
Description (eCommerce)
High mobility group protein 2a (HMG2a) is a member of the Hmg-box subfamily of proteins that possesses a DNA-binding HmG-box domain. The HMG2a gene is X-linked and its expression is localized to the bone marrow and is a marker for hematopoietic stem cells (HSCs). HMG2a plays a role in cell-fate decisions of HSCs and functions by altering DNA structure to facilitate transcription factor binding.
Description (Vector)
HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 (MIM 163905) and HMG2 (MIM 163906), HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (Wilke et al., 1997 (PubMed 9370291); Nemeth et al., 2006 (PubMed 16945912)).(supplied by OMIM, Mar 2008)
Gene ID
3149
Gene Name (eCommerce)
high mobility group box 3
Gene Name (Vector)
high mobility group box 3
Gene Symbol
HMGB3
HGNC ID
HGNC:5004
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
603
Protein Name (eCommerce)
High mobility group protein B3
RefSeq ID
NM_005342
RefSeq Synonyms
NM_005342, NM_001301231, NM_001301229, NM_001301228, BC070482,
Research Areas
Chromatin Remodeling,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
High mobility group protein 2a (HMG2a) is a member of the Hmg-box subfamily of proteins that possesses a DNA-binding HmG-box domain. The HMG2a gene is X-linked and its expression is localized to the bone marrow and is a marker for hematopoietic stem cells (HSCs). HMG2a plays a role in cell-fate decisions of HSCs and functions by altering DNA structure to facilitate transcription factor binding.
UniGene ID
Hs.19114
UniProt ID (eCommerce)
O15347
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.