human FZD6 Over-expression AAV

Name 
AAV-h-FZD6
Cat No 
AAV-209468
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human FZD6.

AAV-209468
AAV-h-FZD6

Ready-to-use AAV expressing Human FZD6 (frizzled class receptor 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
frizzled 6, seven transmembrane spanning receptor; frizzled family receptor 6; frizzled homolog 6; frizzled-6; FZ6; FZ-6; HFZ6; NDNC10; seven transmembrane helix receptor
Description (eCommerce)
Frizzled-6 is a receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin, and activation of wnt target genes. In mice, frizzled-6 is critical to B-cell development.
Description (Vector)
FZD6 represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
Gene ID
8323
Gene Name (eCommerce)
frizzled class receptor 6
Gene Name (Vector)
frizzled class receptor 6
Gene Symbol
FZD6
HGNC ID
HGNC:4044
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2121
ORF Size (bp)
2121 bp
Protein Name (eCommerce)
Frizzled-6
RefSeq ID
NM_003506
RefSeq Synonyms
NM_003506, NM_001317796, NM_001164616, NM_001164615, BC060836,
Research Areas
Angiogenesis,Axonogenesis,Cancer,GPCR Signaling,Hippo Signaling,Host-Virus Interactions,Neurobiology,Neurodevelopment,Signal Transduction,Wnt Signaling
Research Areas (Faceted)
cancer,signal_transduction,developmental_biology,neurobiology,developmental_biology,signal_transduction,infectious_disease,neurobiology,developmental_biology,signal_transduction
Species
human
Target Sentence
Frizzled-6 is a receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin, and activation of wnt target genes. In mice, frizzled-6 is critical to B-cell development.
UniGene ID
Hs.591863
UniProt ID (eCommerce)
O60353

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.