human FZD6 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FZD6.
shADV-209468
Ad-h-FZD6-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FZD6 (frizzled class receptor 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
frizzled 6, seven transmembrane spanning receptor; frizzled family receptor 6; frizzled homolog 6; frizzled-6; FZ6; FZ-6; HFZ6; NDNC10; seven transmembrane helix receptor
Description (eCommerce)
Frizzled-6 is a receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin, and activation of wnt target genes. In mice, frizzled-6 is critical to B-cell development.
Description (Vector)
FZD6 represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
Gene ID
8323
Gene Name (eCommerce)
frizzled class receptor 6
Gene Name (Vector)
frizzled class receptor 6
Gene Symbol
FZD6
HGNC ID
HGNC:4044
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2121
ORF Size (bp)
2121 bp
Protein Name (eCommerce)
Frizzled-6
RefSeq ID
NM_003506
RefSeq Synonyms
NM_003506, NM_001317796, NM_001164616, NM_001164615, BC060836,
Research Areas
Angiogenesis,Axonogenesis,Cancer,GPCR Signaling,Hippo Signaling,Host-Virus Interactions,Neurobiology,Neurodevelopment,Signal Transduction,Wnt Signaling
Research Areas (Faceted)
cancer,signal_transduction,developmental_biology,neurobiology,developmental_biology,signal_transduction,infectious_disease,neurobiology,developmental_biology,signal_transduction
Species
human
Target Sentence
Frizzled-6 is a receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin, and activation of wnt target genes. In mice, frizzled-6 is critical to B-cell development.
UniGene ID
Hs.591863
UniProt ID (eCommerce)
O60353
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.