mouse FZD6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Fzd6.
shAAV-259751
AAV-m-FZD6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Fzd6 (frizzled class receptor 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Fz6
Description (Vector)
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Gene ID
14368
Gene Name (Vector)
frizzled class receptor 6
Gene Symbol
Fzd6
ORF Size (aa)
2130
ORF Size (bp)
2130 bp
RefSeq ID
NM_008056
RefSeq Synonyms
NM_008056, NM_001162494, BC026150,
Species
mouse
UniGene ID
Mm.4769
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.