human EYA2 Over-expression AAV

Name
AAV-h-EYA2

Cat No
AAV-208208

Availability
4-5 weeks

This is an AAV expressing Human EYA2.

AAV-208208

AAV-h-EYA2

Ready-to-use AAV expressing Human EYA2 (EYA transcriptional coactivator and phosphatase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EAB1; eyes absent homolog 2

Description (eCommerce)

EYA2 (eyes absent homolog 2) functions as a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX. EYA2 promotes efficient DNA repair by dephosphorylating H2AX and promoting the recruitment of DNA repair complexes containing MDC1. EYA2 coactivates SIX1. Together with SIX1 and DACH2 EYA2 seems to be involved in myogenesis. EYA2 may be involved in development of the eye [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00167].

Description (Vector)

EYA2 encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined.

Gene ID

2139

Gene Name (eCommerce)

EYA transcriptional coactivator and phosphatase 2

Gene Name (Vector)

EYA transcriptional coactivator and phosphatase 2

Gene Symbol

EYA2

HGNC ID

HGNC:3520

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1545

ORF Size (bp)

1545 bp

Protein Name (eCommerce)

Eyes absent homolog 2

RefSeq ID

NM_005244

RefSeq Synonyms

NM_172110, NM_005244, BC008803,

Research Areas

Apoptosis,DNA Damage/Repair,Histone Modification,Kinase/Phosphatase,Mitochondrion,Phosphatase,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,genetics,signal_transduction,transcription_translation

Species

human

Target Sentence

EYA2 (eyes absent homolog 2) functions as a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX. EYA2 promotes efficient DNA repair by dephosphorylating H2AX and promoting the recruitment of DNA repair complexes containing MDC1. EYA2 coactivates SIX1. Together with SIX1 and DACH2 EYA2 seems to be involved in myogenesis. EYA2 may be involved in development of the eye [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00167].

UniGene ID

Hs.472877

UniProt ID (eCommerce)

O00167

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.