human CDKN2C Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-204884
Availability:
3-5 weeks
Name:
AAV-h-CDKN2C
This is an AAV expressing Human CDKN2C.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- CDKN2C
- Gene Name
- cyclin dependent kinase inhibitor 2C
- Gene ID
- 1031
- Gene Synonyms
- INK4C; p18; p18-INK4C
- ORF Size
- 507 bp
- RefSeq#
- BC005041
- Gene Description
- CDKN2C is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
- UniGene ID
- Hs.716664
- HGNC ID
- HGNC:1789
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