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human BCL11A Over-expression AAV

Name 
AAV-h-BCL11A
Cat No 
AAV-202034
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BCL11A.

AAV-202034
AAV-h-BCL11A

Ready-to-use AAV expressing Human BCL11A (B-cell CLL/lymphoma 11A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
B-cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2; B-cell lymphoma/leukemia 11A; BCL-11A; BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1; BCL11A-L; BCL11a-M; BCL11A-S; BCL11A-XL; C2H2-type zinc finger protein; COUP-TF-interacting protein 1; CTIP1; DILOS; ecotropic viral integration site 9 homolog; ecotropic viral integration site 9 protein homolog; EVI9; EVI-9; HBFQTL5; zinc finger protein 856; ZNF856
Description (eCommerce)
Bcl11a is a transcription factor that functions in B cell hematopoiesis and the generation of B lineage progenitors. Bcl11a has been identified as an oncogene involved in lymphoma pathogenesis and may function as a modulator of ARP1 transcriptional repression.
Description (Vector)
BCL11A encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
Gene ID
53335
Gene Name (eCommerce)
B cell CLL/lymphoma 11A
Gene Name (Vector)
B-cell CLL/lymphoma 11A
Gene Symbol
BCL11A
HGNC ID
HGNC:13221
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2322
ORF Size (bp)
2322 bp
Protein Name (eCommerce)
B-cell lymphoma/leukemia 11A
RefSeq ID
NM_018014
RefSeq Synonyms
NM_138559, NM_022893, NM_018014, BC021098,
Research Areas
Gene Expression,Immunology,Neurobiology,Neurodevelopment,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,developmental_biology,immunology,neurobiology,transcription_translation
Species
human
Target Sentence
Bcl11a is a transcription factor that functions in B cell hematopoiesis and the generation of B lineage progenitors. Bcl11a has been identified as an oncogene involved in lymphoma pathogenesis and may function as a modulator of ARP1 transcriptional repression.
UniGene ID
Hs.370549
UniProt ID (eCommerce)
Q9H165

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.