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human BCL11A shRNA silencing Adenovirus

Name 
Ad-h-BCL11A-shRNA
Cat No 
shADV-202034
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human BCL11A.

shADV-202034
Ad-h-BCL11A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human BCL11A (B-cell CLL/lymphoma 11A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
B-cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2; B-cell lymphoma/leukemia 11A; BCL-11A; BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1; BCL11A-L; BCL11a-M; BCL11A-S; BCL11A-XL; C2H2-type zinc finger protein; COUP-TF-interacting protein 1; CTIP1; DILOS; ecotropic viral integration site 9 homolog; ecotropic viral integration site 9 protein homolog; EVI9; EVI-9; HBFQTL5; zinc finger protein 856; ZNF856
Description (eCommerce)
Bcl11a is a transcription factor that functions in B cell hematopoiesis and the generation of B lineage progenitors. Bcl11a has been identified as an oncogene involved in lymphoma pathogenesis and may function as a modulator of ARP1 transcriptional repression.
Description (Vector)
BCL11A encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
Gene ID
53335
Gene Name (eCommerce)
B cell CLL/lymphoma 11A
Gene Name (Vector)
B-cell CLL/lymphoma 11A
Gene Symbol
BCL11A
HGNC ID
HGNC:13221
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2322
ORF Size (bp)
2322 bp
Protein Name (eCommerce)
B-cell lymphoma/leukemia 11A
RefSeq ID
NM_018014
RefSeq Synonyms
NM_138559, NM_022893, NM_018014, BC021098,
Research Areas
Gene Expression,Immunology,Neurobiology,Neurodevelopment,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,developmental_biology,immunology,neurobiology,transcription_translation
Species
human
Target Sentence
Bcl11a is a transcription factor that functions in B cell hematopoiesis and the generation of B lineage progenitors. Bcl11a has been identified as an oncogene involved in lymphoma pathogenesis and may function as a modulator of ARP1 transcriptional repression.
UniGene ID
Hs.370549
UniProt ID (eCommerce)
Q9H165

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.