human MDR1 shRNA Adenovirus

Name 
Ad-h-MDR1-shRNA
Cat No 
1848
Availability
Immediate
Categories
Adenovirus, shRNA-Silencing

This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown human MDR1 gene. The shRNA expression is driven by an U6 promoter.

The knockdown of this human gene was validated by western blot in CaCo2 cells.

1848
Ad-h-MDR1-shRNA

Ready-to-use human MDR1 shRNA Adenovirus. human MDR1 shRNA adenovirus gene knockdown1848

$995.00
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Product Details

Promoter
U6 ()
Reporter
eGFP
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
ABC20; ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; CD antigen CD243; CD243; CLCS; colchicin sensitivity; doxorubicin resistance; GP170; MDR1; multidrug resistance protein 1; P glycoprotein; P-glycoprotein 1; P-GP; PGY1
Description (eCommerce)
Multidrug resistance protein 1 (MDR1) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). MDR1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. MDR1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. MDR1 also functions as a transporter in the blood-brain barrier [taken from NCBI Entrez Gene (Gene ID: 5243)].
Description (Vector)
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
Gene ID
5243
Gene Name (eCommerce)
ATP binding cassette subfamily B member 1
Gene Name (Vector)
ATP binding cassette subfamily B member 1
Gene Symbol
ABCB1
HGNC ID
HGNC:40
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3843
ORF Size (bp)
3843 bp
Protein Name (eCommerce)
Multidrug resistance protein 1
RefSeq ID
NM_000927
RefSeq Synonyms
NM_000927, BC130424,
Research Areas
Cancer,Cardiology,Cardiovascular,Cell Cycle,Golgi Apparatus,Hypoxia,Metabolism/Metabolic Process,MicroRNAs in Cancer,Neurobiology,Transport
Research Areas (Faceted)
cancer,genetics,cardiovascular,cell_biology,cell_cycle,metabolism,neurobiology,cell_biology
Species
human
Target Sentence
Multidrug resistance protein 1 (MDR1) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). MDR1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. MDR1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. MDR1 also functions as a transporter in the blood-brain barrier [taken from NCBI Entrez Gene (Gene ID: 5243)].
UniGene ID
Hs.489033
UniProt ID (eCommerce)
P08183

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.