human GSK3B shRNA Adenovirus

glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B

Glycogen synthase kinase 3 beta (GSK3beta) is a proline-directed serine-threonine kinase identified as a kinase responsible for the phosphorylation and inactivation of glycogen synthase. GSK3beta is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. In addition to the Wnt-signaling pathway, GSK3beta is also involved in the Hedgehog, Notch and insulin signaling pathways.

GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

2932

glycogen synthase kinase 3 beta

glycogen synthase kinase 3 beta

GSK3B

HGNC:4617

9606.0

1263

1263 bp

Glycogen synthase kinase-3 beta

NM_002093

NM_002093, NM_001146156, BC012760, BC000251,

Alzheimer's Disease,Apoptosis,Autophagy,Axon Guidance,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Colorectal Cancer,Cytoskeleton,DNA Damage/Repair,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,Hedgehog Signaling,Hippo Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,LKB1 Signaling,Metabolism/Metabolic Process,mTOR Signaling,Neurobiology,Neurodegeneration,Neurodevelopment,Neurogenesis,NFAT Signaling,NGF Signaling,Notch Signaling,p53 Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prolactin Signaling,Prostate Cancer,RNA Binding,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,Transcription Factor/Regulator,TWEAK Signaling,VEGF Signaling,Wnt Signaling

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology

human

Glycogen synthase kinase 3 beta (GSK3beta) is a proline-directed serine-threonine kinase identified as a kinase responsible for the phosphorylation and inactivation of glycogen synthase. GSK3beta is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. In addition to the Wnt-signaling pathway, GSK3beta is also involved in the Hedgehog, Notch and insulin signaling pathways.

Hs.593022

P49841